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High Density Microarray
In 2005, when I posted this picture of a DNA microarray, printing 14,000 probes on a 3 square inches glass slide was considered state of the art. Moore's Law, first used to describe the growth of transistor density in microprocessors, is now the name of the game in the world of functional genomics.
This is our first result with a whole genome microarray that contains 240,797 probes. The image that you see here represent only 1.7% of the entire array surface. In just a few years, we have gone from duplicate probes for each of the 6054 genes in the genome of the fungal pathogen Candida albicans to a tiling array that covers all of the DNA in its chromosomes. In this experiment, the red spots mark small regions of the DNA that are bound by a protein that only recognizes specific DNA sequences and that acts as a regulator of gene expression.
December 20, 2007 |
Science
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