Scientific Publications

D. Xiang, R. Datla, F. Li, A. Cutler, M.R. Malik, J. Krochko, N. Sharma, P. Fobert, F. Georges, G. Selvaraj, E. Tsang, D. Klassen, C. Koh, J.-S. Deneault, A. Nantel, J. Nowak, W. Keller, F. Bekkaoui. Development of a Brassica seed cDNA microarray. Genome. In Press, 2008.

J.-F. Marquis, A. Nantel, R. LaCourse, L. Ryan , R.J. North, P. Gros. Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary 2 infection with Mycobacterium tuberculosis in mice. Infect. Immun. (76) 78-88, 2008

T. Haque, D. Faury, S. Albrecht, E. Lopez-Aguilar, P. Hauser, M. Garami, Z. Hansely, L. Bognar, J. Atkinson, A. Nantel, N. Jabado. Gene expression profiling from formalin-fixed paraffin embedded tumors of pediatric glioblastoma. Clin. Cancer Res. (13) 6284-6292, 2007.

T.T. Liu., S. Znaidi, K.S. Barker, L. Xu, R. Homayouni, S. Saidane, J. Morschhäuser, A. Nantel, M. Raymond, P. D. Rogers. Genome-wide expression and location analyses of the Candida albicans Tac1p regulon. Eukaryot. Cell. EC.00327-07v1 , 2007.

S. Znaidi, X. De Deken, S. Weber, T. Rigby, A. Nantel, M. Raymond. The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans. Mol. Microbiol. (66) 440-52, 2007.

M. Martchenko, A. Levitin, W. Chiranand, H. Hogues, A. Nantel, M. Gustin, M. Whiteway. Transcription rewiring within the galactose metabolism circuitry of Candida albicans. Curr. Biol. (17) 1007-13, 2007.

S. Kebache, J. Ash, M.G. Annis, J. Hagan, M. Huber, J. Hassard, C.L. Stewart, M. Whiteway, A. Nantel. Grb10 and Raf-1 cooperate in survival signaling leading to the inactivation of the proapoptotic protein Bad. J. Biol. Chem. (282) 21873-83, 2007.

J.-C. Marshall, A. Nantel, P. Blanco, J. Ash, S.R. Cruess, E. Achenson, M.N. Burnier Jr. Transcriptional profiling of the evolution of uveal melanoma from cell lines to intraocular tumors to metastasis. Clin. Exp. Metastasis. (24) 353-62, 2007.

G.A. Diaz-Quijada, R. Peytavi, A. Nantel, E. Roy, M.G. Bergeron, M.M. Dumoulin, T. Veres. Towards the plastic biochip for high throughput screening devices. Lab on a Chip. (7) 856-62, 2007.

M. van het Hoog, T. Rast (joint first authors), M. Martchenko, S. Grindle, S. Scherer, D. Dignard, H. Hogues, M. Berriman, C. Cuomo, B.B. Magee, H. Chibana, M. Whiteway, A. Nantel, P.T. Magee. Assembly of the Candida albicans genome into 16 supercontigs aligned on the 8 chromosomes. Genome Biol. (8) R52, 2007.

A. Nantel and D. Faury (joint first authors), T. Haque, M.-C. Guiot, P. Hauser, M. Garami, L. Bognár, Z. Hanzé, P. P. Liberski, E. Lopez-Aguilar, E. Valera, A.-S. Carret, R. Del Mastro, S. Albrecht, and N. Jabado. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma. J. Clinical Oncology. (25) 1196-208, 2007.

F. Delom, A. Emadali, E. Cocolakis, J.-J. Lebrun, A. Nantel, E. Chevet. Calnexin-dependent regulation of tunicamycin-induced apoptosis in breast carcinoma MCF-7 cells. Cell Death & Diff. (14) 586-96, 2007.

M. Gray-Mitsumune, M. O’Brien, C. Bertrand, F. Tebbji, A. Nantel, D.P. Matton. Loss of ovule identity induced by overexpression of the Fertilization-Related Kinase 2 (ScFRK2), a MAPKKK from Solanum chacoense. J. Exper. Bot. 57:4171-87, 2006.

A. Nantel, T. Rigby, H. Hogues, M. Whiteway. Microarrays for studying pathology in Candida albicans. Book chapter in “Medical Mycology: Cellular and Molecular Techniques” (Wiley Press). K. Kavanaugh Eds., 2006.

U. Oberholzer, A. Nantel, J. Berman, M. Whiteway. Gene expression profiles of C. albicans cortical actin patch mutants reflect their cellular defects: contribution of the Hog1p and Mkc1p signaling pathways. Eukaryot. Cell. (5) 1252-1265, 2006.

S. Ralph, C. Oddy, D. Cooper, H. Yueh, S. Jancsik, N. Kolosova, R.N. Philippe, D. Aeschliman, R. White, D. Huber, C.E. Ritland, F. Benoit, T. Rigby, A. Nantel, Y.S.N. Butterfield, R. Kirkpatrick, E. Chun, J. Liu, D. Palmquist, B. Wynhoven, J. Stott, G. Yang, S. Barber, R.A. Holt, A. Siddiqui, S.J.M. Jones, M.A. Marra, B.E. Ellis, C.J. Douglas, K. Ritland and J. Bohlmann. Genomics of hybrid poplar (Populus trichocarpa x deltoides) interacting with forest tent caterpillars (Malacosoma disstria): Normalized and full-length cDNA libraries, expressed sequence tags (ESTs), and a cDNA microarray for the study of insect-induced defenses in poplar. Mol. Ecology. (15)1275-1297, 2006.

A. Nantel. The long hard road to a completed Candida albicansgenome. Fungal Genet. and Biol. (43) 311-315, 2006.

M. Whiteway, A. Nantel. Morphogenetic signaling in Candida albicans. Book chapter in "The Mycota: A comprehensive treatise on fungi as experimental systems for basic and applied research" (Springer Press). K. Esser, A.J.P Brown Eds. 147-159, 2006.

C. Bachewich, A. Nantel, M. Whiteway. Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans. Mol. Microbiology. (57) 942-959, 2005.

B.R. Braun, M. van het Hoog, C. D’Enfert, M. Martchenko, J. Dungan, A. Kuo, D.O. Inglis, M.A. Uhl, H. Hogues, M. Berriman, M. Lorenz, A. Levitin, U. Oberholzer, C. Bachewich, D. Harcus, A. Marcil, D.Dignard, T. Iouk, R. Zito, L. Frangeul, F. Tekaia, K. Rutherford, E. Wang, C.A. Munro, S. Bates, N.A. Gow, L.L. Hoyer, G. Köhler, J. Morschhäuser, G. Newport, S. Znaidi, M. Raymond, B. Turcotte, G. Sherlock, M. Costanzo, J. Ihmels, J. Berman, D. Sanglard, N. Agabian, A.P. Mitchell, A.D. Johnson, M. Whiteway, A. Nantel. A human-curated annotation of the Candida albicans genome. PLoS-Genet. (1) e1, 2005.

D. Harcus, A. Nantel, A. Marcil, T. Rigby, M. Whiteway. Transcription profiling of cyclic AMP signalling in Candida albicans. Mol. Biol. Cell. (15) 4490-4499, 2004.

S. Nicholls, M. Straffon, B. Enjalbert, A. Nantel, S. Macaskill, M. Whiteway and A.J.P. Brown. Msn2/4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen, Candida albicans. Eukaryot. Cell. (3) 1111-1123, 2004.

A. Nantel. Visualizing proteome homologies in fungi. GeneSpring Application Note, 2004.

C.-M. Lee, A. Nantel, M. Whiteway, S.-H. Shen. The serine/threonine protein phosphatase Sit4p modulates yeast-to-hyphae morphogenesis and virulence in Candida albicans. Mol. Microbiology. (51) 691-709, 2004.

G. Min-Oo, A. Fortin, M.-F. Tam, A. Nantel, M.M. Stevenson, P. Gros. Pyruvate kinase deficiency is associated with protection against malaria. Nature Genet. (35) 357-362, 2003.

A. Nantel. Visualizing biological complexity. Pharmacogenomics. (4) 697-700, 2003.

B. Enjalbert, A. Nantel, M. Whiteway. Stress induced gene expression in Candida albicans: Absence of a general stress response. Mol. Biol. Cell. (14) 1460-1467, 2003.

A. Nantel. Production of ligand-specific mutants using the yeast two-hybrid assay. Book chapter in "Methods in Molecular Biology, vol 218: Cancer Cell Signaling: Methods and Protocols" (Humana Press). D. M. Terrian Eds. 269-276, 2003.

A. Nantel, D. Dignard, C. Bachewich, D. Harcus, A. Marcil, A.-P. Bouin, C.W. Sensen, H. Hogues, M. van het Hoog, P. Gordon, T. Rigby, F. Benoit, D.C. Tessier, D.Y. Thomas and M. Whiteway. Transcription profiling of C. albicans cells undergoing the yeast to hyphal transition. Mol. Biol. Cell. (13) 3452-3465, 2002.

L.E. Cowen, A. Nantel, D. Tessier, M. Whiteway, D.Y. Thomas , L.M. Kohn, J.B. Anderson. Population genomics of drug resistance in experimental populations of Candida albicans. Proc. Nat. Acad. Sci. USA. (99) 9284-9289, 2002.

C. Mounier, L. Lavoie, V. Dumas, K. Mohammad-Ali, J. Wu, A. Nantel, J.J.M. Bergeron, D.Y. Thomas and B.I. Posner. Specific inhibition by hGrb10z of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mol. Cell. Endocrinol. (173) 15-27, 2001.

A. Nantel, Maria Huber and D.Y. Thomas. Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool. J. Biol. Chem. (274) 35719-35724, 1999.

A. Nantel, K. Mohammad-Ali, J. Sherk, B.I. Posner and D.Y. Thomas. Interaction of the Grb10 adaptor protein with the Raf-1 and MEK1 kinases. J. Biol. Chem. (273) 10475-10484, 1998.

A. Nantel and R.S. Quatrano. Characterization of three rice basic/leucine zipper factors, including two inhibitors of EmBP-1 DNA-binding activity. J. Biol. Chem. (271) 31296-31305, 1996.

A. Hill, A. Nantel, C.R. Rock and R.S. Quatrano. The product of the Viviparous-1 gene enhances the DNA-binding activity of EmBP-1. J. Biol. Chem. (271) 3366-3374, 1996.

A. Nantel, J. Medina and R.S. Quatrano. An improved protocol for library screening by protein:protein interactions with biotinylated proteins. Plant Mol. Biol. Reptr. (13) 164-173, 1995.

A. M. Nantel, F. Lafleur, R. Boivin, C. L. Baszczynski and G. Bellemare. Promoter for a Brassica napus ribulose bisphosphate carboxylase/oxygenase small subunit gene binds numerous nuclear factors and contains a negative strand open reading frame encoding a putative transmembrane protein. Plant Mol. Biol. (16) 955-966, 1991.

Invited Presentations

05/2007: Importance of the Grb10/Raf-1 complex in anti-apoptotic signaling and Bad phosphorylation. Annual General Meeting of the NRC Genome Health Initiative. Halifax, NS.

03/2007: Importance of the Grb10/Raf-1 complex in anti-apoptotic signaling and Bad phosphorylation. GTCbio: Apoptosis in Drug Discovery, San Diego, CA.

03/2007: Transcriptional rewiring in Candida albicans. Systems Biology: Molecular Networks, Montreal Clinical Research Institute, Montreal, QC.

10/2006: Validation of blood biomarkers with Reverse Plase Protein Arrays. 5th Montreal Microarray Symposium, Biotechnology Research Institute, Montreal, QC.

05/2006: Functional genomics in Candida albicans. Keynote presentation at the 2nd Big Sky Yeast Meeting. Montana State University, Bozeman, MT.

03/2006: Final assembly of the Candida albicans genome. ASM Conference on Candida and Candidiasis. Denver, CO.

11/2005: Functional genomics of the fungal pathogen Candida albicans. Departmental seminar. Dept. of Biochemistry, Université de Sherbrooke, Sherbrooke, QC.

06/2005: A human-curated annotation of the fungal pathogen Candida albicans. General Meeting of the American Society for Microbiology, Atlanta, GA.

03/2005: I’m not a mathematician but I play one on TV. Workshop on Computational Biology in the Post-Genomic Era – a collaborative workshop between universities, NRC and Industry. CRM, Université de Montréal, Montreal, QC.

11/2004: Scaffolding proteins and the organization of anti-apoptotic signaling pathways. Departmental Seminar. Dept. of Biology, McGill University, Montreal, QC.

10/2004: Functional genomic studies of the fungal pathogen Candida albicans. Departmental Seminar. Dept. of Biology, Concordia University, Montreal, QC.

06/2004: Basic principles and applications of DNA chips and microarrays. One-day course, Health Canada, Ottawa, ON.

05/2004: Coordinating genome annotations and transcriptional profiles in Candida albicans. Annual General Meeting of the NRC Genome Health Initiative. Montreal, QC.

03/2004: A human-curated annotation of the Candida genome. Report from the Candida Annotation Working Group. ASM Meeting on Candida and Candidasis, Austin, TX.

09/2003: Combining gene ontology with sequence similarity across multiple genomes. CHI Meeting on Data Visualization and Interpretation, Baltimore, MD.

08/2003: Final annotation and assembly of the Candida albicans genome. Annual General Meeting of the NRC Genomic Health Initiative. Saskatoon, Saskatchewan.

08/2003: Transcriptional profiling and chromosome mapping in Candida albicans. Special seminar. University of California at San Francisco, CA.

03/2003: Determination of the chromosomal localization of Candida albicans DNA sequence contigs. Montreal Microarray Symposium, Biotechnology Research Institute, Montreal, QC.

02/2003: Use of microarray analysis software as a novel tool to visualize comparative genomics data. Interim session chair. CHI Meeting on Informatics And Microarray Data Analysis: Deciphering the Data Deluge, Zurich, Switzerland.

02/2003: Coping with the unexpected: Deciphering the functions of the Grb10 adapter protein. Special seminar. Institut für Molekularbiologie, University of Zurich, Switzerland.

02/2003: Transcriptional profiling in the fungal pathogen Candida albicans. Departmental seminar. Institute of Microbiology, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.

02/2003: Transcriptional profiling in Candida albicans. Special seminar. Institute of Medical Sciences, University of Aberdeen, United Kingdom.

06/2002: Using GeneSpring to Visualize Homologies Between Proteomes and in the Study of Dimorphism in Fungi. GeneSpring European Users Conference, Stockholm, Sweden.

12/2001: Using DNA microarrays to analyze Grb10 mouse knockouts, Candida albicans pathogenesis and comparative genomics. Departmental seminar. National Cancer Institute, Frederick, MD.

09/2001: Learning to swim from the middle of a lake: Interpreting results from Candida albicans microarrays. Montreal Microarray Workshop, Biotechnology Research Institute, Montreal, QC.

02/1998: The adapter protein Grb10 is localized to the mitochondria and binds the MEK1 and Raf-1 kinases. Departmental seminar. Dept. of Anatomy and Cell Biology, McGill University, Montreal, QC.